Abstract #0499

Intra-Subject Stability and Reproducibility of 7 T FID-CRT-MRSI

Philipp Lazen¹, Benjamin Spurny-Dworak², Wolfgang Bogner^3,4, Lukas Hingerl³, Bernhard Strasser³, Rupert Lanzenberger², Karl Rössler¹, Siegfried Trattnig^3,4,5, and Gilbert Hangel^1,3

¹Department of Neurosurgery, Medical University of Vienna, Vienna, Austria, ²Division of General Psychiatry, Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria, ³High-field MR Center, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria, ⁴Christian Doppler Laboratory for MR Imaging Biomarkers, Vienna, Austria, ⁵Institute for Clinical Molecular MRI, Karl Landsteiner Society, St. Pölten, Austria

Synopsis

Keywords: Spectroscopy, BrainWe evaluated the intra-subject stability of CRT-FID-MRSI at 7 T in a cohort of 15 volunteers. Two magnetic resonance spectroscopic imaging acquisitions were performed consecutively and metabolite concentration estimates (CEs) were calculated using internal water referencing. The resulting metabolic maps were segmented in 55 brain regions. For analysis, the CEs of both acquisitions were compared and coefficients of variations (CVs) were calculated. We saw high stability in almost all volunteers, with CVs being well below 5% in the brain regions generally associated with good data quality.

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