Abstract #0501

Differential MRS results in a clinical multisite study depending on site harmonization and analysis approach

Parker L La¹, Tiffany K Bell¹, William Craig², Quynh Doan³, Miriam H Beauchamp⁴, Roger Zemek⁵, Keith O Yeates⁶, and Ashley D Harris¹

¹Radiology, University of Calgary, Calgary, AB, Canada, ²University of Alberta and Stollery Children's Hospital, Edmonton, AB, Canada, ³University of British Columbia, Vancouver, BC, Canada, ⁴University of Montreal and St Justine Hospital, Montreal, QC, Canada, ⁵University of Ottawa and Children's Hospital of Eastern Ontario, Ottawa, ON, Canada, ⁶Psychology, University of Calgary, Calgary, AB, Canada

Synopsis

Keywords: Spectroscopy, Brain, Traumatic Brain InjuryThe use of multiple sites and scanners is commonly used to increase sample size; however, this introduces unwanted variance into spectroscopy data. In this work we compare statistical co-variate techniques in combination with ComBat harmonization using data from a concussion study. We show traditional statistical methods of accounting for multi-site variance (using covariates to control for site and vendor) could result in erroneous interpretation of clinical data. Our data supports the use of ComBat harmonization and suggests how to best control for multisite data statistically.

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