Abstract #0502

Glutamate and its relation to cortical thickness and perfusion across the cingulate cortex

Jessica Archibald¹, Erin L. MacMillan^2,3, Niklaus Zölch⁴, and John L.K. Kramer⁵

¹Experimental Medicine, University of British Columbia, Vancouver, BC, Canada, ²ImageTech, Simon Fraser University, Surey, BC, Canada, ³Philips, Markham, ON, Canada, ⁴Psychiatry and Forensic Medicine, Universität Zürich, Zürich, Switzerland, ⁵Anesthesiology, Pharmacology and Therapeutics, University of British Columbia, Vancouver, BC, Canada

Synopsis

Keywords: Spectroscopy, Neuro, neuroscienceInvestigating the relationships between morphological, functional, and metabolic changes in the brain can help reveal subtle changes caused by disease. To establish an understanding of the relationship between brain glutamate levels with cortical thickness (CT) and cerebral blood flow (CBF) in the healthy brain, magnetic resonance spectroscopy (MRS), arterial spin labeled MRI and anatomical MRI were obtained from 4 sub-divisions of the cingulate cortex. A linear mixed effects model revealed that glutamate was significantly correlated with CT (p=0.05, R²=0.30) but not with CSF (p=0.21, R²=0.17) within healthy participants. These results will help inform studies of disease or therapeutic interventions.

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