Keywords: Spectroscopy, BrainThe prefrontal cortex plays a central role in controlling executive functions such as decision-making and emotional-monitoring and has thus been the subject of several 1H-MRS studies on psychiatric illnesses. This region, however, is sensitive to motion-induced increases in linewidths due to the voxel moving away from the originally shimmed location. Here, we combined metabolite cycling (MC) with continuous prospective frequency correction to better account for frequency instabilities when performing single-voxel brain MRS at 7T. We find that MC sLASER with continuous prospective frequency correction reduces frequency instability, water linewidths, and N-acetylaspartate linewidths relative to semi-LASER acquisitions without prospective frequency correction.
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