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Abstract #0506

Characterization of small bowel strictures in Crohn’s disease with multiparametric MRI

Emre Altinmakas1, Himanshu Sharma2, Octavia Bane1,3, Ghadi Abboud1, Alex Menys4, Yansheng Hao5, Jean-Frederic Colombel6, Noam Harpaz5, and Bachir Taouli1,3
1Department of Diagnostic, Molecular and Interventional Radiology, Icahn School of Medicine at Mount Sinai, New York, NY, United States, 2Icahn School of Medicine at Mount Sinai, NY, NY, United States, 3BioMedical Engineering and Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States, 4Motilent Ltd, London, United Kingdom, 5Department of Pathology, Icahn School of Medicine at Mount Sinai, NY, NY, United States, 6Department of Gastroenterology, Icahn School of Medicine at Mount Sinai, New York, NY, United States

Synopsis

Keywords: Digestive, Quantitative Imaging, Crohn's disease; stricture; mpMRI;Small bowel stricture (SBS) is the one of the most common complications of Crohn’s Disease (CD) and it usually requires surgical management. Imaging diagnosis and characterization of SBS is essential for proper patient management, however this may be challenging with conventional MRI techniques. In current study, we investigate the utility of advance MRI techniques namely multiparametric MRI (mpMRI) including diffusion, perfusion, and motility in the characterization and tissue composition in CD-related SBS. Our preliminary results suggest that mpMRI parameters are promising tools to characterize SBS and may be helpful in the stratification of patients for medical treatment vs surgery.

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