Abstract #0515

Magnetic resonance elastography-derived stiffness: potential biomarker for differentiation of benign and malignant pancreatic masses

Dingxia Liu¹, Jiejun Chen¹, Yunfei Zhang², Yongming Dai², and Xiuzhong Yao¹

¹Shanghai Institute of Medical Imaging, Shanghai, China, ²MR Collaboration, Central Research Institute, United Imaging Healthcare, Shanghai, China

Synopsis

Keywords: Pancreas, Cancer

Magnetic resonance elastography (MRE) is a noninvasive technique capable of quantifying tissue mechanical properties (stiffness) in vivo. Given its specialty, it is supposed to be potential for identifying malignant tumors that are characterized by a marked desmoplastic reaction and build-up of fibrotic tissues in cancer cells and tumor microenvironment. However, the field has been largely restricted to studies in pancreatic MRE. This study sought to determine the diagnostic performance of MRE for pancreatic solid masses, compared with diffusion-weighted imaging (DWI) and serum CA19-9, to establish a threshold for differentiating between pancreatic ductal adenocarcinoma (PDAC) and benign tumors in pancreas.

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