Abstract #0539

Rapid Mesoscale MP2RAGE Imaging at Ultra High Field with Controlled Aliasing

Gabriel Varela-Mattatall^1,2, Wei-Ching Lo³, Omer Oran⁴, Jonathan Polimeni^5,6, Azma Mareyam^5,7, Borjan Gagoski^8,9, Ravi S. Menon^1,2, and Berkin Bilgic^5,6

¹Centre for Functional and Metabolic Mapping (CFMM), Robarts Research Institute, Western University, London, ON, Canada, ²Department of Medical Biophysics, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada, ³Siemens Medical Solutions USA, Boston, MA, United States, ⁴Siemens Healthcare Limited, Oakville, ON, Canada, ⁵Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital & Harvard Medical School, Boston, MA, United States, ⁶Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Boston, MA, United States, ⁷Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Boston, Boston, MA, United States, ⁸Fetal-Neonatal Neuroimaging & Developmental Science Center, Boston Children’s Hospital, Boston, MA, United States, ⁹Department of Radiology, Harvard Medical School, Boston, MA, United States

Synopsis

Keywords: Data Acquisition, New Trajectories & Spatial Encoding MethodsMP2RAGE is considered the workhorse sequence at ultra-high field (UHF) as it provides high-contrast and bias-free structural imaging for both anatomical and segmentation purposes. However, high-resolution MP2RAGE imaging is hampered by lengthy acquisitions, which can be partially mitigated using parallel imaging, but this comes at the cost of g-factor and √R penalties on SNR; thus, limiting the usefulness of this sequence at the submillimeter scale. In this work, we show preliminary results on how wave encoding, and blipped-controlled aliasing could allow efficient MP2RAGE acquisitions at up to 560 um isotropic resolution at 7T.

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