Abstract #0541

Mesoscale distortion-free in-vivo dMRI at 7T using ROtating-view Motion-robust supEr Resolution EPTI (Romer-EPTI)

Zijing Dong^1,2, Jonathan R. Polimeni^1,2,3, Lawrence L. Wald^1,2,3, and Fuyixue Wang^1,2

¹Athinoula A. Martinos Center for Biomedical Imaging, MGH, Charlestown, MA, United States, ²Department of Radiology, Harvard Medical School, Charlestown, MA, United States, ³Harvard-MIT Health Sciences and Technology, MIT, Cambridge, MA, United States

Synopsis

Keywords: Data Acquisition, BrainPushing the spatial resolution of diffusion MRI to mesoscale is technically challenging due to the low SNR efficiency and severe image artifacts. Last year, we presented a novel ROtating-view Motion-robust supEr Resolution Echo Planar Time-resolved Imaging method (Romer-EPTI), providing significant gains (~3.5×) in SNR efficiency and high-quality images free from distortion with minimized motion artifacts. In this work, we further developed Romer-EPTI at 7T for in-vivo mesoscale dMRI. By exploiting the higher signal of 7T and the short-TE, high-SNR, distortion-free acquisition provided by Romer-EPTI, mesoscale whole-brain dMRI at an unprecedented 485-μm isotropic resolution was acquired.

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