Abstract #0556

Free-running 5D whole-heart MRI with ferumoxytol enhancement to evaluate cardiac function in congenital heart disease

Salim Aymeric Si-Mohamed^1,2, Ludovica Romanin³, Mariana Falcao³, Jerome Yerly², Estelle Tenisch², Tobias Rutz², Charles De Bourguignon⁴, Jurg Schwitter⁵, Matthias Stuber³, Christopher Roy², and Milan Prsa⁶

¹Radiology department, University of Lyon, Lyon, France, ²CIBM, CHUV, Lausanne, Switzerland, ³CIBM, CHUV, Lausanne, France, ⁴Research radiology department, Hospices Civiles de Lyon, Lyon, France, ⁵Cardiology, CHUV, Lausanne, Switzerland, ⁶Pediatric cardiology department, CHUV, Lausanne, France

Synopsis

Keywords: Cardiomyopathy, Data Analysis, cardiac functionFree-running 5D whole-heart imaging (5D CMR) has been proposed as a means of simplifying CMR exams by capturing the entire 3D cardiac anatomy without the need for ECG gating or breath-holds. We demonstrated that 5D CMR with ferumoxytol enhancement enables the evaluation of cardiac function in comparison to ECG gated 2D CINE images in congenital heart disease patients. In addition, it enables evaluation of the cardiac morphology with improved diagnostic quality in ~40% of the cases. This suggests that the free-running approach has the potential for replacing the conventional 2D imaging for evaluation of both cardiac function and morphology.

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