Abstract #0563

Intra- and inter-session reliability of lumbar spinal cord resting-state fMRI

Anna JE Combes^1,2, Grace Sweeney¹, Delaney Houston¹, Logan Prock¹, Lipika Narisetti¹, Baxter P Rogers^1,2, Colin D McKnight², John C Gore^1,2,3, Seth A Smith^1,2,3, and Kristin P O'Grady^1,2,3

¹Vanderbilt University Institute of Imaging Science, Vanderbilt University Medical Center, Nashville, TN, United States, ²Radiology & Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN, United States, ³Biomedical Engineering, Vanderbilt University Medical Center, Nashville, TN, United States

Synopsis

Keywords: Spinal Cord, fMRI (resting state)We investigated the intra- and inter-session reliability of functional connectivity indices derived from resting-state fMRI in the lumbar spinal cord. Slicewise and average indices of connectivity for the ventral and dorsal networks were collected across three experiments in healthy participants at 3T. Intra-session reliability was high for back-to-back scans (ICC>0.9), and moderate-to-good when introducing repositioning, surveying and reshimming (COV=3-25%). Repeatability of indices across separate visits was low, although similar grey matter functional networks could be independently observed and showed high spatial overlap using ICA, a data-driven approach. This is the first evaluation of resting-state fMRI reliability in the lumbar cord.

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