Abstract #0571

7T fMRI in the Cervical Spinal Cord Under Noxious Thermal Stimulation

Alan C Seifert^1,2,3 and S Johanna Vannesjo⁴

¹Biomedical Engineering and Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States, ²Department of Radiology, Icahn School of Medicine at Mount Sinai, New York, NY, United States, ³Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, United States, ⁴Department of Physics, Norwegian University of Science and Technology (NTNU), Trondheim, Norway

Synopsis

Keywords: Spinal Cord, Spinal CordFMRI of the spinal cord is challenging due to its small size, necessitating high resolution. Increasing B₀ to 7T enables higher spatial resolution, and also enhances BOLD signal. However, challenges related to B₀ homogeneity complicate spinal cord fMRI at 7T. We present group-level stimulus task fMRI results in the spinal cord at 7T, and compare the performance of single-shot and multi-shot 2D EPI protocols. Single-shot at 0.75mm in-plane resolution was most sensitive to activation, while multi-shot at 0.60mm provided the best-localized clusters. The best choice of protocol depends on the importance of sensitivity versus spatial localization for a given experiment.

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