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Abstract #0572

Realizing sub-second and sub-millimeter spinal cord fMRI at 7 Tesla

D Rangaprakash1 and Robert L Barry1
1Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, United States

Synopsis

Keywords: Spinal Cord, fMRI (resting state)Spinal cord fMRI is an emerging field with clinical potential. Sub-millimeter in-plane fMRI acquisitions are desirable and achievable, but published studies have had modest temporal resolutions (>2s). Using a custom-built 7T spine coil, we demonstrate sub-second and sub-millimeter cervical cord fMRI for the first time. Employing a 3D multi-shot sequence with appropriate phase corrections and NORDIC denoising, our data demonstrated temporal signal-to-noise ratios similar to those of standard supra-second protocols, and we replicated functional connectivity patterns previously published in the cord. This opens new avenues of discovery similar to those realized through high spatiotemporal resolution brain fMRI.

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