Abstract #0573

Harmonization of Spinal Cord Diffusion Tensor Imaging Data from a Multi-Site, Multi-Scanner Study using Longitudinal ComBat

Devon M Middleton¹, Yutong Li², Andrew Chen³, Russell T Shinohara³, John H Woo³, Adam E Flanders¹, Scott H Faro¹, Laura Krisa², and Feroze B Mohamed¹

¹Radiology, Thomas Jefferson University, Philadelphia, PA, United States, ²Thomas Jefferson University, Philadelphia, PA, United States, ³University of Pennsylvania, Philadelphia, PA, United States

Synopsis

Keywords: Spinal Cord, Diffusion Tensor ImagingThis study uses longitudinal ComBat data harmonization on a multi-site/multi-scanner spinal cord DTI study with a traveling cohort imaged on four scanners. The results show considerable improvement in correlation between scanners as well as decerased coefficient of variation. This approach has potential benefits for large, multi-site spinal cord studies.

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