Abstract #0578

A Method for Detection of Subtle Blood-Brain Barrier Disruption using Non-Contrast MR Fingerprinting

Emma L Thomson^1,2, Elizabeth Powell¹, Claudia A M Gandini Wheeler-Kingshott^3,4,5, and Geoff J M Parker^1,6,7

¹Centre for Medical Image Computing, Department of Medical Physics and Biomedical Engineering, University College London, London, United Kingdom, ²UCL Queen Square Institute of Neurology, Faculty of Brain Sciences, London, United Kingdom, ³NMR Research Unit, Queen Square MS Centre, Department of Neuroinflammation, London, United Kingdom, ⁴Department of Brain & Behavioural Sciences, University of Pavia, Pavia, Italy, ⁵Brain Connectivity Centre Research Department, IRCCS Mondino Foundation, Pavia, Italy, ⁶NMR Research Unit, Queen Square MS Centre, Department of Neuroinflammation, UCL Queen Square Institute of Neurology, Faculty of Brain Sciences, London, United Kingdom, ⁷Bioxydyn Limited, Manchester, United Kingdom

Synopsis

Keywords: Neurodegeneration, Blood vesselsUsing magnetic resonance fingerprinting (MRF), we propose a method for regional quantification of blood volume (ν_b) and BBB water exchange (by quantifying capillary water residence time, τ_b), as a metric of BBB function/dysfunction. A single axial slice was acquired for seven healthy volunteers using an MRF SPGR sequence. Matching to a precomputed dictionary was performed to simultaneously quantify intra and extravascular T₁, B₁⁺, ν_b, and τ_b. Initial findings in volunteers show that it is possible to quantify these five parameters simultaneously. Our results show promise for patient studies of blood-brain barrier disruption.

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