Abstract #0579

Investigating application of multi-echo, multi-delay arterial spin labeling (ASL) to study endothelial exchange of water

Swati Rane Levendovszky¹, Lena Vaclavu², Jaqueline Flores¹, Elaine Peskind³, Jeffrey Iliff³, and Matthias J.P. van Osch²

¹Radiology, University of Washington School of Medicine, Seattle, WA, United States, ²C.J. Gorter MRI Center, Radiology, Leiden University Medical Center, Leiden, Netherlands, ³Mental Illness Research, Education and Clinical Center, VA Puget Sound, Seattle, WA, United States

Synopsis

Keywords: Neurodegeneration, Perfusion, sleep, agingWe applied multi-echo Hadamard encoded ASL imaging to study blood flow (CBF) and trans-endothelial exchange of water (T_ex) as markers of vascular function to study two common risk factors of dementia; aging and sleep deprivation. We found that older adults had significantly lower CBF, and shorter T_ex compared to young adults. In the same young adults, we compared CBF and T_ex after a normal night of sleep and after sleep deprivation. Both CBF and T_ex were insignificantly lower when measured after sleep deprivation compared to measurements after normal sleep.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.