Abstract #0581

Region-specific characteristics of brain oxygen extraction fraction: relationships to aging and white matter hyperintensities

Jie Song¹, Wen Shi², Kaisha Hazel³, George Pottanat³, Ebony Jones³, Cuimei Xu³, Doris Lin³, Sevil Yasar⁴, Marilyn Albert⁵, Hanzhang Lu³, and Dengrong Jiang³

¹Department of Biomedical Engineering, Johns Hopkins University School of Engineering, Baltimore, MD, United States, ²Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ³Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ⁴Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD, United States, ⁵Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, United States

Synopsis

Keywords: Neurodegeneration, AgingAging is a multifaceted process involving both structural and metabolic alterations. Cerebral oxygen-extraction-fraction (OEF) is an important physiological parameter indexing the brain’s oxygen metabolism. In this work, we assessed regional OEF in young and older adults, and investigated its associations with aging and white-matter-hyperintensities. We observed significant age-related increase in cortical OEF but not in subcortical OEF, suggesting that aging may have different effects on tissue metabolism in cortical and subcortical regions. Furthermore, we found a significant inverse correlation of WMH with OEF in internal-cerebral-veins, implying that OEF of subcortical structures may be useful in predicting WMH.

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