Abstract #0589

Multicompartment Imaging of the Brain Using a Comprehensive MR Imaging Protocol

James Lo^1,2, Eric Y. Chang^1,3, Jiang Du^1,2,3, Graeme M Bydder¹, and Yajun Ma¹

¹Department of Radiology, University of California San Diego, San Diego, CA, United States, ²Department of Bioengineering, University of California San Diego, San Diego, CA, United States, ³Radiology Service, Veteran Affairs San Diego Healthcare System, San Diego, CA, United States

Synopsis

Keywords: Neurodegeneration, Quantitative Imaging, MyelinIn this study, we developed a comprehensive MR imaging protocol to quantify all the major components of the brain. This protocol includes four different kinds of sequences: a magnetization transfer prepared Cones (MT-Cones) for two-pool MT modeling, a short-TR adiabatic inversion-recovery prepared Cones (STAIR-Cones) for myelin water imaging, a proton-density weighted Cones (PDw-Cones) for total water imaging, and a highly T₂ weighted Cones (T₂w-Cones) for extracellular water imaging. Using a combination of these techniques, we successfully quantified the proton fractions of brain macromolecules, myelin water, intracellular water, and extracellular water components in three healthy volunteers with a 3T clinical scanner.

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