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Abstract #0591

Brain and cervical spinal cord myelination and age-related changes in adulthood: a preliminary study based on ihMTsat and T1 relaxometry mapping

Arash Forodighasemabadi1,2,3,4, Lucas Soustelle1,2, Olivier M. Girard1,2, Thomas Troalen5, Jean-Philippe Ranjeva1,2, Guillaume Duhamel1,2, and Virginie Callot1,2,4
1Aix-Marseille Univ, CNRS, CRMBM, Marseille, France, 2APHM, Hopital Universitaire Timone, CEMEREM, Marseille, France, 3Aix-Marseille Univ, Université Gustave Eiffel, LBA, Marseille, France, 4iLab-Spine International Associated Laboratory, Montreal, Canada, Marseille, France, 5Siemens Healthcare SAS, Saint-Denis, France

Synopsis

Keywords: Neurodegeneration, Aging

Inhomogeneous Magnetization Transfer (ihMT) has shown to be a biomarker of myelin with enhanced specificity as compared to conventional MT. To compensate for B1+ and T1 effects, a 3D ihMT-RAGE sequence with an ihMTsat framework has recently been proposed.

In this study, ihMTsat was used in combination with an optimized MP2RAGE sequence to study both brain and spinal cord adulthood aging process.

The ihMTsat and R1=1/T1 metrics followed an inverse U-shaped evolution with age in different ROIs, from which a maturation age was extracted. A multiparametric (R1,ihMTsat) voxel-wise analysis revealed significant age effect in the microstructure of different cord tracts.

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Keywords