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Abstract #0593

MR Imaging Deep Brain Stimulation of the Nucleus Basalis Meynert Restored Cognitive Function in Alzheimer’s Disease Model

Ching-Wen Chang1,2, Yi-Chen Lin1, Chiung-Yuan Ko3, Yu-Chun Lo3, Ting-Chieh Chen1, Ssu-Ju Li1, Mu-Hua Wang1, Tsai-Yu Cho1, Sheng-Huang Lin4,5, and You-Yin Chen1,3
1Department of Biomedical Engineering, National Yang Ming Chiao Tung University, Taipei, Taiwan, 2Biomedical Translation Research Center, Academia Sinica, Taipei, Taiwan, 3Ph.D. Program in Medical Neuroscience, Taipei Medical University, Taipei, Taiwan, 4Department of Neurology, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan, 5Department of Neurology, Tzu Chi University, Hualien, Taiwan

Synopsis

Keywords: Neurodegeneration, fMRI, Nucleus Basalis of MeynertAlzheimer’s disease (AD) is an intricate neurodegenerative disease. Nucleus Basalis of Meynert (NBM), a key region of the cholinergic system that provides acetylcholine to cortex, has been shown to be target for deep brain stimulation (DBS) in AD. The 5×FAD mouse model was used to investigate the change of behavioral tasks, resting-state functional MRI, and acetylcholinesterase (AChE) assay were applied in this study. We found that NBM-DBS may play an important role in modulating cognitive function and spatial working memory in 5×FAD mice. Increasing functional connectivity and decreasing AChE activity may be the biomarkers for AD individuals.

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