Keywords: Neurodegeneration, fMRI, Nucleus Basalis of MeynertAlzheimer’s disease (AD) is an intricate neurodegenerative disease. Nucleus Basalis of Meynert (NBM), a key region of the cholinergic system that provides acetylcholine to cortex, has been shown to be target for deep brain stimulation (DBS) in AD. The 5×FAD mouse model was used to investigate the change of behavioral tasks, resting-state functional MRI, and acetylcholinesterase (AChE) assay were applied in this study. We found that NBM-DBS may play an important role in modulating cognitive function and spatial working memory in 5×FAD mice. Increasing functional connectivity and decreasing AChE activity may be the biomarkers for AD individuals.
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