Abstract #0595

Comparison of measured and simulated cardiac magnetostimulation thresholds in eight pigs

Valerie Klein^1,2,3, Livia Vendramini¹, Mathias Davids^1,2, Natalie G. Ferris^1,4, Lothar R. Schad³, David E. Sosnovik^1,2,4,5, Christopher T. Nguyen^6,7,8, Lawrence L. Wald^1,2,4, and Bastien Guérin^1,2

¹A. A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA, United States, ²Harvard Medical School, Boston, MA, United States, ³Computer Assisted Clinical Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany, ⁴Harvard-MIT Division of Health Sciences and Technology, Cambridge, MA, United States, ⁵Cardiovascular Research Center, Cardiology Division, Massachusetts General Hospital, Charlestown, MA, United States, ⁶Cardiovascular Innovation Research Center, Heart Vascular & Thoracic Institute, Cleveland Clinic, Cleveland, OH, United States, ⁷Cardiovascular Imaging, Imaging Institute, Cleveland Clinic, Cleveland, OH, United States, ⁸Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, United States

Synopsis

Keywords: Safety, Bioeffects & Magnetic FieldsWe use a combined electromagnetic-electrophysiological modeling framework to predict cardiac stimulation (CS) thresholds in individualized porcine body models and compare those simulations to thresholds measured in eight pigs using strong dB/dt pulses. For all pigs, the simulated and measured thresholds agree within 30%, and no significant differences between simulations and measurements were detected (p<0.05, paired t-test). The threshold model uncertainty was found to be ~25% in a sensitivity analysis of the relevant model parameters. A well-validated model may help inform appropriate safety limits for MRI gradients to protect patients from CS without overly restricting gradient performance.

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