Abstract #0617

Characterisation of laminar spatiotemporal dynamics of CBV and BOLD signals using fast sampling at 7T fMRI in humans

Sebastian Dresbach^1,2, Renzo Huber^1,3, Omer Faruk Gulban^1,4, Alessandra Pizzuti^1,4, Robert Trampel², Dimo Ivanov¹, Rainer Goebel^1,4, and Nikolaus Weiskopf^2,5

¹Department of Cognitive Neuroscience, Faculty of Psychology and Neuroscience, Maastricht University, Maastricht, Netherlands, ²Department of Neurophysics, Max-Planck-Institut for Human Cognitive and Brain Science, Leipzig, Germany, ³National institute of Health, Bethesda, DC, United States, ⁴Brain Innovation B.V., Maastricht, Netherlands, ⁵Felix Bloch Institute for Solid State Physics, Faculty of Physics and Earth Sciences, Leipzig University, Leipzig, Germany

Synopsis

Keywords: fMRI, NeuroscienceCharacterisation of cortical laminar activity requires detailed knowledge of the spatiotemporal haemodynamic response across vascular compartments. Additionally, laminar models of the BOLD-response are dependent on CBF and CBV responses to neural activity. Therefore, we characterised the depth-dependent CBV- and BOLD-haemodynamic responses across varying stimulus durations with 0.9mm spatial, 0.785s effective temporal resolution. Furthermore, we obtained fine-scale vascular details using ME-GRE data at 0.35mm to investigate signal contributions from different vascular compartments. Our results contribute to the understanding of the laminar VASO response, provide guidance for neuroscientific applications, and support modelling of the laminar haemodynamic responses in humans.

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