Abstract #0619

Optimized signal saturation for fast functional line-scanning of cortical layers

Nils Nothnagel¹, Tyler Morgan², Alison Symon¹, Lars Muckli¹, and Jozien Goense^3,4,5

¹School of Psychology & Neuroscience, University of Glasgow, Glasgow, United Kingdom, ²NIH, Bethesda, MD, United States, ³Beckman Institute for Advanced Science and Technology, Urbana, IL, United States, ⁴Department of Psychology, University of Illinois at Urbana-Champaign, Champaign, IL, United States, ⁵Department of Bioengineering, University of Illinois at Urbana-Champaign, Urbana, IL, United States

Synopsis

Keywords: fMRI, High-Field MRI, High Resolution fMRILayer-dependent fMRI is typically performed at sampling rates below 1 Hz and voxel sizes of 0.7-0.9 mm³ containing signal from multiple anatomical layers. Line-scanning can enhance spatial resolution to 0.2-0.4 mm while maintaining sub-second TR. It is therefore an ideal method to study temporal evolution of BOLD responses across cortical layers. However, current saturation schemes for human line-scanning suffer from broad saturation profiles that lead to signal contamination of BOLD responses from adjacent areas. We implemented line-scanning in humans with sharp line-profiles of 3 mm. Using this method, we show that cortical layers of M1 have unique BOLD time courses.

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