Abstract #0621

Layer-specific functional connectivity with 3D VAPER fMRI

Yuhui Chai¹, A. Tyler Morgan², Hua Xie³, Linqing Li⁴, Laurentius Huber⁴, Peter A. Bandettini^2,4, and Bradley P. Sutton¹

¹Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL, United States, ²Section on Functional Imaging Methods, NIMH, NIH, Bethesda, MD, United States, ³Children's National Hospital, Washington DC, DC, United States, ⁴Functional MRI Core, NIMH, NIH, Bethesda, MD, United States

Synopsis

Keywords: Brain Connectivity, fMRI, fMRI connectivityWe introduced a whole-brain 3D VAPER sequence tool and analysis approach for layer-specific resting state fMRI. It allows investigation of the directional connectivity between brain areas and determine whether any given connection is better described as predominantly feedforward vs. feedback driven. To exemplify this, we demonstrated that different directions of the same connection within the default mode network (mPFC <-> PCC/Parietal region) lead to different laminar correlation profile, suggesting different projection types (feedforward/feedback).

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