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Abstract #0623

Layer-resolved FMRI activation and connectivity of the left inferior frontal cortex during reading

Daniel Sharoh1, Peter Hagoort1,2, and David G Norris1,3,4
1Donders Institute, Radboud University, Nijmegen, Netherlands, 2Max Planck Institute for Psycholinguistics, Nijmegen, Netherlands, 3Erwin L. Hahn Institute for Magnetic Resonance Imaging, University of Duisburg-Essen, Essen, Germany, 4Faculty of Science and Technology, Magnetic Detection and Imaging, University Twente, Enschede, Netherlands

Synopsis

Keywords: Brain Connectivity, fMRI (task based), Laminar FMRIWe present results which demonstrate simultaneous bottom-up and top-down connectivity from BA44 to regions hierarchically inferior/superior to it in the context of a reading paradigm. BA44 is critical to a number of cognitive functions in humans, notably language. We also demonstrate that the layer dependent signal is sensitive to stimulus length. This effect is contrary to what would be expected in primary sensory cortices, as increased length relates to decreased input. Hence, we also provide insight to how canonical cortico-cortical circuits can lead to different outcomes depending on the nature of the input and the stage of the processing hierarchy.

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