Abstract #0644

A common brain network underlying successful neuromodulatory treatment of Obsessive-Compulsive Disorder

Jurgen Germann¹, Gavin JB Elias¹, Emily HY Wong¹, Kazuaki Yamamoto², Artur Vetkas¹, Flavia V Gouveia³, Aaron Loh¹, Alexandre Boutet¹, and Andres M Lozano¹

¹University Health Network, Toronto, ON, Canada, ²Functional Neurosurgery Center, Shonan Fujisawa Tokushukai Hospital, Fujisawa, Japan, ³Neuroscience and Mental Health, Hospital for Sick Children Research Institute, Toronto, ON, Canada

Synopsis

Keywords: Psychiatric Disorders, Psychiatric Disorders, Obsessive-compulsive disorderObsessive-compulsive disorder (OCD) is a debilitating condition, with up to 20% of patients being refractory to medical treatment. For these severe cases, neuromodulatory techniques targeting distinct brain areas have been successful. In this work, we used normative functional connectomics to identify the brain network underlying symptom improvement in OCD. A pan-modality efficacy map identified cortical and subcortical areas as key regions, and this specific network could be used to successfully predict clinical improvement. These results suggest that symptom reduction following neuromodulation involves the engagement of a common functional network that could be investigated as a biomarker of treatment success.

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