Keywords: Psychiatric Disorders, PET/MR, QSM, 7T, Tourette Syndrome, PET, Dopamine, Receptors, D1We present interim results of the first combined 7T MRI and [11C]-SCH23390 PET study in Gilles de la Tourette syndrome (GTS). Dopamine D1-receptor availability is assessed in combination with Quantitative Susceptibility Mapping (QSM). Our results indicate reduced iron concentrations in subcortical grey matter of GTS patients compared to age- and sex-matched controls, accompanied by reduced D1-receptor binding potential in several regions. Correlations between local iron distribution and D1-receptor binding potential in basal ganglia support the hypothesis that iron homeostasis might play a significant role in dysregulations of the dopaminergic system that eventually lead to the characteristic symptomatology of GTS.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords