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Abstract #0646

7T MRI and PET in Tourette Syndrome: Correlations between subcortical dopamine receptor availability and susceptibility

Dimitrios G. Gkotsoulias1, Michael Rullmann2, Simon Schmitt3, Anna Bujanow1, Franziska Zientek2, Konstantin Messerschmidt2, Kirsten Müller-Vahl3, Henryk Barthel2, and Harald E. Möller4
1NMR Group, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany, 2Department of Nuclear Medicine, University of Leipzig, Leipzig, Germany, 3Clinic of Psychiatry, Social Psychiatry and Psychotherapy, Hannover Medical School, Hannover, Germany, 4Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany

Synopsis

Keywords: Psychiatric Disorders, PET/MR, QSM, 7T, Tourette Syndrome, PET, Dopamine, Receptors, D1We present interim results of the first combined 7T MRI and [11C]-SCH23390 PET study in Gilles de la Tourette syndrome (GTS). Dopamine D1-receptor availability is assessed in combination with Quantitative Susceptibility Mapping (QSM). Our results indicate reduced iron concentrations in subcortical grey matter of GTS patients compared to age- and sex-matched controls, accompanied by reduced D1-receptor binding potential in several regions. Correlations between local iron distribution and D1-receptor binding potential in basal ganglia support the hypothesis that iron homeostasis might play a significant role in dysregulations of the dopaminergic system that eventually lead to the characteristic symptomatology of GTS.

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