Keywords: Psychiatric Disorders, Microstructure Sleep has been hypothesized to assist waste clearance from the brain. We aimed to determine whether primary insomnia is associated with glymphatic system dysfunction by using diffusion tensor imaging (DTI) with the perivascular space (DTI-ALPS), a potential marker of impaired brain waste clearance. In this study, we found that the DTI-ALPS in patients with primary insomnia was significantly lower than in healthy controls and the DTI-ALPS index was significantly negatively correlated with neuropsychological performance score. The results suggests that DTI-ALPS may be a useful imaging tool for studying glymphatic system function with primary insomnia.
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