Keywords: Psychiatric Disorders, Quantitative Imaging, Psychiatric disorders, Neuroscience, Multi-ContrastMany psychiatric conditions lack radiologic markers of disease. In this study, we investigated the utility of quantitative MRI (qMRI) for detecting pathology in the lactational immune activation rat model of schizophrenia and depression. Results show that a logistic regression model can identify the disease with an accuracy of 81% based on a combination of T1 and T2, mean diffusivity, and fractional anisotropy values. This finding suggests that multiparametric qMRI is useful for monitoring pathology with an objective quantitative tool that goes beyond structural deformations and improves the sensitivity to microstructural and neurochemical pathology in the lactational immune activation rat model.
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