Abstract #0651

Normative Modelling of White Matter Microstructure in Early Psychosis and Schizophrenia

Tommaso Pavan^1,2, Yasser Alemán-Gómez^1,2, Raoul Jenni^2,3, Martine Cleusix^2,3, Luis Alameda^2,4, Kim Quang Do Cuenod^2,3, Philippe Conus^2,4, Paul Klauser^2,5, Patric Hagmann^1,2, and Ileana Jelescu^1,2

¹Department of Radiology, Lausanne University Hospital (CHUV), Lausanne, Switzerland, ²University of Lausanne (UNIL), Lausanne, Switzerland, ³Center for Psychiatric Neuroscience, Department of Psychiatry, Lausanne University Hospital (CHUV), Lausanne, Switzerland, ⁴General Psychiatry Service, Treatment and Early Intervention in Psychosis Program (TIPP-Lausanne), Lausanne University Hospital (CHUV), Lausanne, Switzerland, ⁵Center for Psychiatric Neuroscience and Service of Child and Adolescent Psychiatry, Department of Psychiatry, Lausanne University Hospital (CHUV), Lausanne, Switzerland

Synopsis

Keywords: Psychiatric Disorders, Microstructure, Schizophrenia, Neuroinflammation, Neurodegeneration, Microstructure, Diffusion, White MatterThe great majority of studies in schizophrenia (SCHZ) failed to achieve recognizable spatial patterns of the disease due to its heterogeneity. With this abstract, the authors aim to understand WM microstructure patterns from an individual perspective in early psychosis and SCHZ using advanced diffusion MRI metrics, namely diffusion kurtosis imaging (DKI), the WM microstructure model White Matter Tract Integrity – Watson (WMTI-W) and normative modelling, a statistical method for studying individual differences as extreme deviations from the normality. Overall, deviations in SCHZ subjects were twice as frequent when compared to EP or CTRL while EP displayed more spatial heterogeneity.

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