Abstract #0652

Prominent role of cerebellar communication in schizophrenia reflected by resting state fMRI connectivity

Shukti Ramkiran^1,2, Ravichandran Rajkumar^1,2, Claudia Régio Brambilla¹, Linda Orth², Hasan Sbaihat¹, Nicolas Kaulen¹, Jörg Mauler¹, Tanja Veselinović^1,2, Nibal Khudeish¹, Lutz Tellmann¹, Karl-Josef Langen^1,3,4, Christoph Lerche¹, N. Jon Shah^1,3,4,5, and Irene Neuner^1,2

¹Institute of Neuroscience and Medicine - 4 (INM- 4), Forschungszentrum Jülich, Juelich, Germany, ²Department of Psychiatry, Psychotherapy and Psychosomatics, Uniklinik RWTH Aachen, Aachen, Germany, ³Department of Nuclear Medicine, Uniklinik RWTH Aachen, Aachen, Germany, ⁴Department of Neurology, Uniklinik RWTH Aachen, Aachen, Germany, ⁵Institute of Neuroscience and Medicine 11 (INM - 11), Forschungszentrum Jülich, Juelich, Germany

Synopsis

Keywords: Psychiatric Disorders, fMRI (resting state), SchizophreniaSchizophrenia is a complex neuropsychiatric disorder, the pathophysiology of which is unclear. Several studies have shown the involvement of altered brain communication. Several new voxel-level connectivity measures such as radial similarity, radial correlation, inter-hemispheric connectivity and local correlation have enabled a deeper understanding of alterations in communication. Our results reveal the prominent role of the cerebellum in schizophrenia by investigating voxel-level connectivity in resting state fMRI data.

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