Keywords: Psychiatric Disorders, Genetics, Schizophrenia
Cognitive dysfunction is considered to be one of the core symptom dimensions of schizophrenia. To deconstruct the underlying etiological behind cognitive deficits from a more integrated and multidimensional perspective, we established a trans-scale dataset at the level of the individual corresponding to each participant and control, containing blood-sample transcriptome profile, neuroimaging endophenotypes, and cognitive ability. Multivariate correlation analysis and mediation analysis demonstrated that the gene-brain-cognition associations were exsisted in healthy controls, whereas disrupted in patients with schizophrenia. These results provide a preliminary clue in comprehending the misaligned relationship between the microscale biological pathways and macroscopic phenotypes in schizophrenia.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords