Abstract #0655

Cerebral Mapping of Glutamate-Weighted MR Imaging (GluCEST) in a Rat Model of Lipopolysaccharide-Induced Sepsis

Do-Wan Lee¹, Jae-Im Kwon², Hwon Heo³, Chul‐Woong Woo⁴, Yeon Ji Chae³, Na Hee Yu², Seongwon Na⁵, Yousun Ko¹, Nari Kim⁶, Joongkee Min⁴, Monica Young Choi⁴, Kyung Won Kim¹, and Dong‐Cheol Woo^3,4

¹Department of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea, Republic of, ²QuBEST Bio Co. ltd., Gyeonggi-do, Korea, Republic of, ³Department of Convergence Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea, Republic of, ⁴Convergence Medicine Research Center, Asan Institute for Life Sciences, Asan Medical Center, Seoul, Korea, Republic of, ⁵Biomedical Research Center, Asan Institute for Life Sciences, Asan Medical Center, Seoul, Korea, Republic of, ⁶Department of Medical Science, Asan Medical Institute of Convergence Science and Technology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea, Republic of

Synopsis

Keywords: Neuroinflammation, Molecular ImagingGlutamate-weighted chemical exchange saturation transfer (GluCEST) is a useful imaging tool which is used to detect glutamate signal alterations caused by neuroinflammation. The present study quantitatively evaluated glutamate level changes in the hippocampal region of a rat model of sepsis-induced brain injury using GluCEST and proton magnetic resonance spectroscopy (1H-MRS). The GluCEST and 1H-MRS results showed that GluCEST values and glutamate concentrations were significantly higher in the sepsis-induced rats than in the controls. GluCEST imaging could be a helpful technique for defining a biomarker to estimate the glutamate-related metabolism in sepsis-associated diseases.

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