Abstract #0657

DGE MRI detects altered glucose uptake and utilization upon microglia activation in Alzheimer’s disease

Zilin Chen¹, Jianpan Huang¹, Haoyun Su^1,2, Wai Po Chong³, and Kannie W.Y. Chan^1,2,4,5,6

¹Department of Biomedical Engineering, City University of Hong Kong, Hong Kong, China, ²Hong Kong Centre for Cerebro-Cardiovascular Health Engineering (COCHE), Hong Kong, China, ³School of Chinese Medicine, Hong Kong Baptist University, Hong Kong, China, ⁴Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, United States, ⁵City University of Hong Kong Shenzhen Research Institute, Shenzhen, China, ⁶Tung Biomedical Science Centre, City University of Hong Kong, Hong Kong, China

Synopsis

Keywords: Alzheimer's Disease, Neuroscience

Immune cell activation is a hallmark of Alzheimer’s disease (AD). Microglia activation impairs with glucose metabolism, which may serve as early biomarker for AD. Here, we employed dynamic glucose-enhanced (DGE)-MRI to assess glucose uptake and clearance in AD, and study its relationship with microglia based on our previous study. We observed an increase in microglia in AD than WT, accompanied with relatively high parenchymal glucose uptake and low CSF clearance. We believe further studies to associate the underlying molecular and cellular pathology of AD with DGE-MRI could benefit the identification of AD in early stages.

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