Abstract #0658

Diffusion MRI as a marker of neuroinflammation following intracerebral haemorrhage

Josephine Thomas^1,2, Hamied Haroon^2,3, Emmanuel Pinteaux^1,2, Catherine Lawrence^1,2, Stuart M Allan^1,2, and Ben R Dickie^2,4

¹Division of Neuroscience, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester, M13 9PT, Manchester, United Kingdom, ²Geoffrey Jefferson Brain Research Centre, University of Manchester, Manchester Academic Health Science Centre, UK, Manchester, United Kingdom, ³Division of Psychology, Communication & Human Neuroscience, Faculty of Biology, Medicine and Health, The University of Manchester, UK, Manchester, United Kingdom, ⁴Division of Informatics, Imaging and Data Sciences, Faculty of Biology, Medicine and Health, University of Manchester, UK, Manchester, United Kingdom

Synopsis

Keywords: Stroke, InflammationDiffusion tensor imaging (DTI) and neurite orientation and density imaging (NODDI) is used to observe regional changes in brain microstructure following intracerebral haemorrhage (ICH) in rats. On day 7 following ICH, DTI and NODDI metrics were significantly altered in haemorrhaged sub-regions as well as healthy appearing overlying cortex, compared to contralateral tissue. Histological analysis suggest these changes are driven by altered cell density and populations, with notable regional changes in microglia/macrophages. In summary, DTI and NODDI parameters are altered in ICH and may reflect changes in the immune cell populations in both haemorrhaged and overlying normal-appearing cortex.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.