Abstract #0662

A Correlational Study of Changes in Behaviour and MRI Measures in the CNS in the EAE Mouse Model of Multiple Sclerosis

Rania Muhammed¹, Rehman Tariq ², Uche J Ohaezukosi², Qandeel Shafqat², Ying Wu², and Jeff F. Dunn¹

¹University of Calgary, Calgary, AB, Canada, ²Department of Radiology, University of Calgary, Calgary, AB, Canada

Synopsis

Keywords: Multiple Sclerosis, BrainMultiple sclerosis is an inflammatory disease of the central nervous system, with a posited hypoxia-inflammation cycle hypothesis. Hypoxia may increase disease severity in MS. We found R2* was increased (an MRI marker of hypoxia) in the cortex. We observed increased sickness and R2* in EAE mice compared to controls, but reduced CBF in both CFA-PTx and EAE. Inflammation is in both groups, while autoimmunity is only in EAE. Reduced CBF may relate to inflammation, whereas hypoxia may relate to autoimmune-mediated damage and increase disease severity.

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