Keywords: Neurofluids, Alzheimer's Disease, Perivascular spaceEnlargement of perivascular and ventricular spaces are associated with neuroinflammation in neurodegenerative diseases, including cerebral small vessel disease and Alzheimer’s disease. In this study we develop methodology for measuring the anatomy of the perivascular space around the anterior cerebral artery and partial-volume-free estimates of total CSF volume and apply this approach to TgF344-AD rats. Neither the area under the curve of perivascular space profiles, nor overall width of the perivascular space, or the total CSF volume differed between TgF344-AD rats and wild-types.
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