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Abstract #0670

Free-Breathing, Confounder-Corrected, 3D T1 Mapping of the Liver through Simultaneous Estimation of T1, PDFF, R2* and B1+

Yavuz Muslu1,2, Ty A. Cashen3, Sagar Mandava4, Diego Hernando2,5, and Scott B. Reeder1,2,5,6,7
1Department of Biomedical Engineering, University of Wisconsin-Madison, Madison, WI, United States, 2Department of Radiology, University of Wisconsin-Madison, Madison, WI, United States, 3Global MR Applications and Workflow, GE Healthcare, Waukesha, WI, United States, 4Global MR Applications and Workflow, GE Healthcare, Atlanta, GA, United States, 5Department of Medical Physics, University of Wisconsin-Madison, Madison, WI, United States, 6Department of Medicine, University of Wisconsin-Madison, Madison, WI, United States, 7Department of Emergency Medicine, University of Wisconsin-Madison, Madison, WI, United States

Synopsis

Keywords: Quantitative Imaging, Liver, Multi-ContrastT1 relaxation is emerging as a biomarker for the diagnosis and staging of chronic liver disease. Modified Look-Locker Inversion Recovery (MOLLI) is widely used in clinical practice for abdominal T1 mapping; however, current methods are not corrected for fat and B1 inhomogeneities as confounding factors and fail to provide reliable T1 measurements. In this work, we propose a novel, free-breathing, confounder-corrected T1 mapping method over the entire liver, by combining inversion recovery and chemical shift encoding imaging for simultaneous estimation of T1, PDFF, R2* and B1+.

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Abstract Presentation Video

Keywords