Keywords: Quantitative Imaging, Quantitative ImagingThe acquisition of high-resolution quantitative measurements is of particular interest in studying the laminar structure and layer-specific pathology in the cerebral cortex. In this work, we propose a method to address this need by acquiring 1-D echo planar spectroscopic imaging (EPSI) as a "virtual biopsy" with 200 µm resolution along the readout direction. Our sequence yields expected spectra for common compounds and produces high-quality quantitative T2* and off-resonance measurements in ex vivo brain tissue. Our goal is to use this quantitative virtual biopsy to discriminate laminar variations in cortical iron deposition in diseases such as frontotemporal lobar degeneration (FTLD).
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