Keywords: Microstructure, Gray MatterIt is non-trivial to decompose the diffusion MRI signal, as conventionally measured using relatively weak gradients, into contributions from multiple compartments and estimate the cell sizes. Instead, using strong diffusion gradients, a universal compartment-independent localization regime emerges, as they saturate all magnetization except that near cell membranes. The signal sensitivity to the membrane and its surface-to-volume ratio enables the soma size estimation without modeling multiple compartments. Here, we observed the unique functional form of localization regime and estimate the soma size in mouse and pig brains cortical gray matter on a Bruker CryoProbe system.
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