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Abstract #0681

Localization Regime of Diffusion (LoRD) in mouse and pig cortical gray matter and its sensitivity to soma size

Hong-Hsi Lee1,2, Nian Wang3,4, Els Fieremans5, Susie Y Huang1,2, and Dmitry S Novikov5
1Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, United States, 2Radiology, Harvard Medical School, Boston, MA, United States, 3Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, United States, 4Stark Neurosciences Research Institute, Indianapolis, IN, United States, 5Center for Advanced Imaging Innovation and Research, New York University School of Medicine, New York, NY, United States

Synopsis

Keywords: Microstructure, Gray MatterIt is non-trivial to decompose the diffusion MRI signal, as conventionally measured using relatively weak gradients, into contributions from multiple compartments and estimate the cell sizes. Instead, using strong diffusion gradients, a universal compartment-independent localization regime emerges, as they saturate all magnetization except that near cell membranes. The signal sensitivity to the membrane and its surface-to-volume ratio enables the soma size estimation without modeling multiple compartments. Here, we observed the unique functional form of localization regime and estimate the soma size in mouse and pig brains cortical gray matter on a Bruker CryoProbe system.

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