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Abstract #0690

High-SNR whole-brain microstructure diffusion MRI using Romer-EPTI

Fuyixue Wang1,2, Zijing Dong1,2, Hong-Hsi Lee1,2, Susie Y. Huang1,2,3, Jonathan R. Polimeni1,2,3, and Lawrence L. Wald1,2,3
1Athinoula A. Martinos Center for Biomedical Imaging, MGH, Charlestown, MA, United States, 2Department of Radiology, Harvard Medical School, Charlestown, MA, United States, 3Harvard-MIT Health Sciences and Technology, MIT, Cambridge, MA, United States

Synopsis

Keywords: Diffusion/other diffusion imaging techniques, MicrostructureDiffusion MRI is a widely-used non-invasive imaging method for studying tissue microstructure but often suffers from low signal-to-noise ratios when using high b values. Here, we present a diffusion MRI acquisition technique that can achieve significantly higher SNR efficiency while providing distortion-free high-quality images. It achieves high robustness to phase variations and motion and provides an efficient acquisition technique for microstructural diffusion imaging. Ultra-high b-value and time-dependent experiments were performed to evaluate the improved SNR efficiency of Romer-EPTI.

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Keywords