Meeting Banner
Abstract #0691

Detecting temperature-driven microstructural modulations in tissue using diffusion MRI

Jelle Veraart1, Daniel Nunes2, and Noam Shemesh2
1Center for Biomedical Imaging, Dept. Radiology, NYU Grossman School of Medicine, New York, NY, United States, 2Champalimaud Research, Champalimaud Centre for the Unknown, Lisbon, Portugal

Synopsis

Keywords: Diffusion/other diffusion imaging techniques, MicrostructureIn this study, we uncover that the signal fraction of a fully restricted diffusion compartment in fixed white matter tissue, the so-called dot fraction, is dependent on the tissue temperature. In particular, we report a sudden increase in its nominal value of this fraction when the tissue temperature drops below approximately 32°C. The underlying mechanism remains unexplained, but its impact on modeling of ex vivo diffusion MRI cannot be underestimated. The observation corroborates our hypotheses of a temperature-dependent disruption of the multilamellar structure of the myelin sheath, leading to water trapped in vacuoles that are formed in the myelin sheath.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.

Keywords