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Abstract #0706

Deep learning-based segmentations challenge established link between stroke volume and functional outcome after thrombectomy

Ingrid Digernes1, Martin Soria Røvang1, Terje Nome2, Cecilie Nome3, Thor Håkon Skattør2, Brian Anthony Enriquez3, Bradley J MacIntosh1, Anne Hege Aamodt3, and Atle Bjørnerud1
1Computational Radiology and Artificial Intelligence, Oslo University Hospital, Oslo, Norway, 2Radiology and Nuclear Medicine, Oslo University Hospital, Oslo, Norway, 3Department of Neurology, Oslo University Hospital, Oslo, Norway

Synopsis

Keywords: Stroke, Machine Learning/Artificial Intelligence, segmentation, functional outcome, thrombectomyUsing a standard 3D nnUNET model that was pretrained to segment WMH on FLAIR, we obtained good stroke lesion segmentation accuracy (median Dice = 0.80) when the model was re-trained to segment the stroke lesion on DWI in a smaller stroke sample (N = 82). Applying the segmentation model to DWIs from 307 thrombectomy patients, we found no association between pre-treatment lesion volume and functional outcome at 90 days after thrombectomy. Our results indicate that the established assumption of lesion size being a strong predictor of functional outcome should be investigated further for patients receiving mechanical thrombectomy.

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