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Abstract #0714

19F-MRI of pulmonary ventilation: Assessment of response to treatment in asthma and COPD

Mary A Neal1,2, Charlotte Holland1,2, Benjamin J Pippard1,2, Ian Forrest3, Graham Burns3, Rod Lawson4, Holly F Fisher5, John NS Matthews5, A John Simpson2, Jim M Wild6, and Peter E Thelwall1,2
1Newcastle Magnetic Resonance Centre, Newcastle University, Newcastle upon Tyne, United Kingdom, 2Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, United Kingdom, 3Department of Respiratory Medicine, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, United Kingdom, 4Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, United Kingdom, 5Institute of Health and Society, Newcastle University, Newcastle upon Tyne, United Kingdom, 6POLARIS, Imaging Sciences, Department of IICD, University of Sheffield, Sheffield, United Kingdom

Synopsis

Keywords: Lung, Non-Proton, fluorine, 19F, ventilation

19F-MRI is an emerging technique which holds promise for direct, quantitative imaging of pulmonary ventilation without recourse to ionising radiation or use of specialist hyperpolarised gases. We aimed to assess the sensitivity of 19F-MRI to treatment response by imaging inhaled perfluoropropane in patients with asthma and patients with COPD before and after administration of a bronchodilator, at two research sites. Significant increases in percent ventilated lung volume were measured from the 19F-MR images following bronchodilator administration in both patient groups, and a positive correlation with spirometry was measured, demonstrating good technique sensitivity and clinical validity.

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