Abstract #0721

Quantitative DCE-MRI after P4-based error correction provides a more accurate therapy response assessment of pancreatic ductal adenocarcinoma

Martin D Holland¹, Ezinwanne Onuoha², Moh’d Khushman³, Darryl Outlaw³, Mehmet Akce ³, Bassel El-Rayes ³, Grant R Williams ³, Salila Hashmi ⁴, Sushanth Reddy ⁴, J. Bart Rose ⁴, Desiree E. Morgan ⁵, Xiaoyu Jiang ⁶, Dana Cardin ⁷, Katherine Frederick-Dyer ⁶, Junzhong Xu ⁶, and Harrison D Kim⁵

¹Interdisciplinary Engineering, University of Alabama at Birmingham, Birmingham, AL, United States, ²Biomedical Engineering, University of Alabama at Birmingham, Birmingham, AL, United States, ³Medicine, University of Alabama at Birmingham, Birmingham, AL, United States, ⁴Surgery, University of Alabama at Birmingham, Birmingham, AL, United States, ⁵Radiology, University of Alabama at Birmingham, Birmingham, AL, United States, ⁶Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN, United States, ⁷Medicine, Vanderbilt University Medical Center, Nashville, TN, United States

Synopsis

Keywords: Pancreas, Cancer, DCE-MRI, Pancreatic cancer, Therapy monitoring, Perfusion phantom, QuantificationDynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) measures tissue perfusion by monitoring the dynamic change of MRI contrast agents. However, the inter/intra-scanner variability in quantitative DCE-MRI (qDCE) measurement remains a concern. We developed a point-of-care portable perfusion phantom (P4) that can be imaged with a human subject in a standard MRI scanner to detect and correct the inter/intra-scanner variability of qDCE measurement. We demonstrated that the PDAC response to chemotherapy could be accurately assessed using quantitative DCE-MRI after our P4-based error correction method approximately seven weeks after starting therapy in two clinics.

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