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Abstract #0730

Diffusion-relaxation correlation spectroscopic imaging for evaluating response to neoadjuvant therapy in locally advanced rectal cancer

Xixi Zhao1, Wentao Hu2, Honglei Hu1, Chuyao Chen1, Yongming Dai2, and Yikai Xu1
1Department of Medical Imaging Center, Nanfang Hospital, Southern Medical University, Guangzhou, China, 2MR Collaboration, Central Research Institute, United Imaging Healthcare, Shanghai, China

Synopsis

Keywords: Digestive, CancerDifferent treatment strategies should be applied to locally advanced rectal cancer (LARC) patients achieving different response after neoadjuvant chemoradiotherapy (nCRT). The purpose of this study was to determine the diagnostic performance of diffusion-relaxation correlation spectroscopic imaging (DR-CSI) in discriminating the pathological complete response (pCR) to nCRT in LARC. Compared to non-pCR group, pCR group showed significantly decreased average DR-CSI VD. ROC curve analysis indicated that the VD has better diagnostic performance in distinguishing pCR from non-pCR patients than traditional ADC and T2 value.

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