Abstract #0732

Evaluating intra-voxel incoherent motion in the uterine cervix: healthy volunteer repeatability and therapy-induced changes in tumours

Anubhav Datta^1,2, Damien J. McHugh^1,3, Michael J. Dubec^1,3, David L. Buckley^3,4, Ross Little¹, Michael Berks¹, Susan Cheung¹, Catharine West¹, Ananya Choudhury^1,5, Peter Hoskin^1,5,6, and James P. B. O'Connor^1,2,7

¹Division of Cancer Sciences, The University of Manchester, Manchester, United Kingdom, ²Clinical Radiology, The Christie NHS Foundation Trust, Manchester, United Kingdom, ³Christie Medical Physics and Engineering, The Christie NHS Foundation Trust, Manchester, United Kingdom, ⁴School of Medicine, University of Leeds, Leeds, United Kingdom, ⁵Clinical Oncology, The Christie NHS Foundation Trust, Manchester, United Kingdom, ⁶Clinical Oncology, Mount Vernon Cancer Centre, Northwood, United Kingdom, ⁷Division of Radiotherapy and Imaging, Institute of Cancer Research, London, London, United Kingdom

Synopsis

Keywords: Uterus, CancerThere is a need for robust imaging biomarkers which can be used to assess early tumour response to therapy. Intra-voxel incoherent motion (IVIM) can provide information about tumour microstructure and microvasculature, but requires technical and biological validation. This work evaluates IVIM repeatability in the uterine cervix of healthy volunteers, assesses the sensitivity of IVIM parameters to therapy in patients with uterine cervical cancer, and evaluates model suitability through a model comparison framework.

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