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Abstract #0740

Fat fraction dependent decrease of muscle 1H2O T2 in Duchenne muscular dystrophy is steeper in patients with faster disease progression

Eric Baetscher1, William Triplett2, Glenn Walter2, Sean Forbes2, Rebecca Willcocks2, Robert Mueller2, Alison Barnard2, Krista Vandenborne2, and William Rooney3
1Biomedical Engineering, Oregon Health & Science University, Portland, OR, United States, 2University of Florida, Gainesville, FL, United States, 3Oregon Health & Science University, Portland, OR, United States

Synopsis

Keywords: Muscle, RelaxometryFatty tissue replacement of muscle is characteristic of disease progression in Duchenne muscular dystrophy (DMD), and correlates with a decrease in muscle 1H2O T2. We report longitudinal analysis of MRS data from 86 subjects with DMD. We detect a significant effect of μ (age at 50% fat-fraction) on the slope of T2 by FF. The effect of μ on slope is a consequence of lower T2 at high FF in early progressing subjects, not an effect of T2 differences at low FF. The slope of muscle water T2 decline with FF may contain additional information related to pathology in DMD.

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