Abstract #0742

Magnetization transfer ratio for characterizing extra-ocular muscles changes in myasthenia gravis: a pilot feasibility study

Qin Zhou¹, Pei Chen¹, Xiaoxiao Zhao¹, Jing Zhao¹, Mengzhu Wang², and Zhiyun Yang¹

¹The first affiliated hospital of sun yat-sen university, Guangzhou, China, ²MR Scientific Marketing, Siemens Healthineers Ltd, Guangzhou, China

Synopsis

Keywords: Muscle, CEST & MT, Myasthenia Gravis,MTRThis study looked into the feasibility of using MTI to assess the EOM morphological and pathological changes in MG. The MTR can effectively quantify fibrosis and atrophy of EOM in MG patients, which is significantly related to the poor response to medication and the long duration of the disease, implying that it can be used as a non-invasive auxiliary diagnostic tool for MG patients' prognosis evaluation.

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