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Abstract #0759

Quasi-Diffusion: A Model Of Signal Attenuation In Diffusion Magnetic Resonance Imaging Of Brain Tissue

Thomas R Barrick1, Carson Ingo2,3, and Franklyn A Howe1
1Department of Neurosciences, St George's, University of London, London, United Kingdom, 2Department of Neurology, Northwestern University, Chicago, IL, United States, 3Department of Physical Therapy, Human Movement Sciences, Northwestern University, Chicago, IL, United States

Synopsis

Keywords: Signal Modeling, Diffusion/other diffusion imaging techniquesWe show the quasi-diffusion model describes the dMRI signal from low b-value (stretched exponential) to high b-value (power law) regimes via a single, parsimonious function of two independent parameters. We identify new tissue contrast via a signal inflection point indicating the transition to the localisation regime. Quasi-Diffusion Imaging (QDI) parameter estimates converge to stable values as maximum b-value is increased, suggesting quasi-diffusion is a valid model for brain tissue dMRI signal decay. Accuracy of QDI parameters computed from 4 b-values of a 12 b-value acquisition indicate QDI measures may be derived from data acquired in clinically feasible times.

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Keywords