Abstract #0760

Axonal Diameter Mapping using High Performance Gradients: Feasibility study and Repeatability of Estimates

Nastaren Abad¹, Afis Ajala¹, Chitresh Bhushan¹, Ante Zhu¹, Luca Marinelli¹, Eric Fiveland¹, Seung-Kyun Lee¹, J Kevin DeMarco^2,3, Robert Shih^2,3, Maureen Hood^2,3, Gail Kohls², H. Doug Morris³, Kimbra Kenney³, Vincent Ho³, and Thomas K.F Foo^1,3

¹GE Research, Niskayuna, NY, United States, ²Walter Reed National Military Medical Center, Bethesda, MD, United States, ³Uniformed Services University of the Health Sciences, Bethesda, MD, United States

Synopsis

Keywords: Signal Modeling, Diffusion/other diffusion imaging techniquesHigh performance gradients allow for the exploration of an expanded diffusion parameter space, that simplifies biophysical model at ultra-high b=7-30 ms/μm². The choice of b-encoding space can suppress contributions from extra-axonal water signal while utilization of high performance gradient systems allows for maintaining short echo times (TE<63 ms) with adequate SNR. In this study, the feasibility and reproducibility of mapping effective axonal diameter distributions in the in-vivo brain was assessed by making use of a test-retest paradigm. Whole brain white-matter and parcel based reproducibility and sensitivity were evaluated for this promising biomarker.

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